Reversal of fortune

Mark Baxter and I wrote a commentary on this great paper by Rudebeck et al. They showed that the orbitofrontal cortex, a brain region thought to be involved in behavioural flexibility and emotion processing, may actually have a more restricted role than previously thought. Damage to the orbitofrontal cortex in monkeys and in humans can also lead to damage to the white matter tracts passing through it, and if those tracts are spared then the effect of the damage to orbitofrontal cortex is limited. It shows that we should be cautious when interpreting the effects of lesion studies. The orbitofrontal cortex is more likely to have a specific role in goal-directed behaviour and outcome expectation.

Screen Shot 2013-07-29 at 20.33.40Artwork by Katie Vicari

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s